Dante Adams in Rescue the Rescuers uses an M4A1 with a Combat Scope and M203 attached, though it lacks an AN/PEQ-2 laser pointer in this case.
In Neptune's Net, the suppressor returns, yet the Red dot sight is replaced by a Combat scope. Rabbit's M4A1 in Dorothy's a Bitch has a Red dot sight, an AN/PEQ-2 laser emitter, a flashlight and a suppressor attached, yet it loses this suppressor in Compromised. It usually comes with an optical sight attached, as well as an AN/PEQ-2 laser pointer. It has two fire modes: semi-automatic and fully-automatic, and it is advisable to use the semi-auto fire mode in open combat as the M4 burns through ammunition quickly. In the singleplayer, the M4A1 has medium rate of fire and medium damage, as well as medium recoil.